解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:Late diagnosis hinders proper management of small intestine neuroendocrine carcinoma (SI-NEC) patients. The olfactory receptor, family 51, subfamily E, member 1 (OR51E1) has been reported as a potential novel SI-NEC marker, without protein expression recognition. Thus, we further studied whether the encoded p...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0814
更新日期:2013-01-17 00:00:00
abstract:BACKGROUND:Pubertal onset is usually defined by breast development in girls and testicular growth in boys. Pubarche is defined as the attainment of pubic hair and is considered as a sign of pubertal transition. Pubarche is preceded by a gradual increase in production of adrenal androgens, DHEA and Δ4-androstenedione (A...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0191
更新日期:2012-12-31 00:00:00
abstract:OBJECTIVE:Primary aldosteronism (PA) has deleterious effects on kidney function independent of blood pressure levels. Up to now, data on effectiveness of different PA therapies regarding renal function are scarce. DESIGN AND METHODS:This prospective multi-center study included 29 patients with newly diagnosed PA evalu...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1530/EJE-12-0631
更新日期:2012-12-10 00:00:00
abstract:OBJECTIVE:To investigate the long-term effects of antipsychotic (AP) treatment and AP-induced hyperprolactinemia on bone mineral density (BMD) and body composition in male adolescents with autism spectrum disorders (ASDs) and/or disruptive behavior disorder (DBD). DESIGN:Physically healthy 10- to 20-year-old boys with...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0521
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:IGF1 is essential for human growth and mediates its effects through the type 1 IGF receptor (IGF1R). Our objective was to determine the frequency of certain previously reported IGF1R gene variants in the normal population and their effect on stature. DESIGN:A cross-sectional study was conducted in a populati...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0565
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:We conducted a prospective phase II clinical trial to determine the efficacy of sorafenib in patients with advanced radio-iodine refractory differentiated thyroid cancer. In this article, the long-term results are presented. PATIENTS AND METHODS:Thirty-one patients with progressive metastatic or locally adva...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0405
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Individuals carrying a heterozygous inactivating PAX8 mutation are affected by congenital hypothyroidism (CH), although heterozygous Pax8 knockout mice are not. It has remained unclear whether CH in PAX8 mutation carriers is caused by haploinsufficiency or a dominant negative mechanism. OBJECTIVE:To report ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0410
更新日期:2012-11-01 00:00:00
abstract::Orthodenticle homolog 2 (OTX2) is a homeobox family transcription factor required for brain and eye formation. Various genetic alterations in OTX2 have been described, mostly in patients with severe ocular malformations. In order to expand the knowledge of the spectrum of OTX2 mutation, we performed OTX2 mutation scre...
journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
doi:10.1530/EJE-12-0333
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:Thyroidal production of triiodothyronine (T(3)) is absent in patients who have undergone total thyroidectomy. Therefore, relative T(3) deficiency may occur during postoperative levothyroxine (L-T(4)) therapy. The objective of this study was to evaluate how the individual serum T(3) level changes between preop...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-1029
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:C-peptide, a cleavage product of insulin, exerts biological effects in patients with type 1 diabetes mellitus, but its role in type 2 diabetes mellitus is controversial. Our aim was to examine the associations between fasting C-peptide levels and all-cause mortality, specific-cause mortality and the incidence...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0085
更新日期:2012-08-01 00:00:00
abstract:AIM:To characterize the clinical phenotype of type 2 diabetes mellitus (T2DM) with respect to age, gender, and BMI. METHOD:Anonymized data of 120,183 people with T2DM from the German/Austrian multicenter Diabetes Patienten Verlaufsdokumentation database were analyzed based on chronological age or age at diagnosis (0-1...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0143
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:The risk of radiation-induced benign and malignant thyroid nodules is well known. OBJECTIVE:The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematolog...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0073
更新日期:2012-08-01 00:00:00
abstract::CLTA4 is relevant for FOXP3(+)Treg cells, and the link between skewed X chromosome inactivation (XCI) and autoimmunity is recognized. The observation of immune dysregulation polyendocrinopathy enteropathy X-linked syndrome and multiorgan endocrine autoimmune phenomena in various members of one family, associated with ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0197
更新日期:2012-07-01 00:00:00
abstract:CONTEXT:Vitamin D deficiency has been identified as a risk factor for a number of autoimmune diseases including type 1 diabetes and multiple sclerosis. OBJECTIVE:We hypothesized that low levels of vitamin D are related to the early stages of autoimmune thyroid disease (AITD). DESIGN:Two case-control studies were perf...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0048
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Serum IGF-binding protein 2 (IGFBP2) concentrations are reduced in obese humans and increase after a prolonged period of fasting. We investigated the association between IGFBP2 levels and mortality together with other factors that are related to IGFBP2, including the metabolic syndrome and physical function. ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0160
更新日期:2012-07-01 00:00:00
abstract::Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-12-0167
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The aim was to evaluate changes of bone mineral density (BMD) and markers of bone turnover in healthy adolescents, and in adolescent users of combined oral contraceptives (COCs) with different ethinylestradiol (EE) contents. METHODS:In this prospective crossover study, 56 healthy females (15-19.5 years) wit...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-1047
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To study the prevalence of renal stones and nephrocalcinosis in patients with primary hyperparathyroidism (PHPT) and to appraise biochemical variables as risk factors for developing renal calcifications. DESIGN:Cross-sectional. MATERIALS AND METHODS:All patients (n=177) undergoing diagnostic evaluation and ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0032
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:A stress reaction involving increased cortisol release, which has not been documented thus far, might affect the assessment of selectivity of catheterization during adrenal venous sampling (AVS). OBJECTIVE:To investigate whether an ACTH-driven cortisol release occurs during AVS and whether it influences the...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0972
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Testicular Leydig cell tumours (LCTs) are rare, steroid-secreting tumours. Elevated levels of aromatase (CYP19 or CYP19A1) mRNA have been previously described in LCTs; however, little is known about the mechanism(s) causing CYP19 over-expression. We report an LCT in a 29-year-old male with ele...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0849
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures and thiazolidinediones (TZDs) increase this risk. TZDs stimulate the expression of sclerostin, a negative regulator of bone formation, in vitro. Abnormal sclerostin production may, therefore, be involved in the pathogenesis of i...
journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1530/EJE-11-1061
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Confirmatory testing of suspected primary aldosteronism (PA) requires an extensive medication switch that can be difficult for patients with severe complicated hypertension and/or refractory hypokalemia. For this reason, we investigated the effect of chronic antihypertensive medication on confirmatory testing...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
doi:10.1530/EJE-11-0914
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Elevated levels of circulating fibroblast growth factor 21 (FGF21) are commonly encountered in type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, all of which share exaggerated postprandial lipemia as a common proatherogenic feature. How FGF21 responds to an oral fat load in man is unknown...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0783
更新日期:2012-03-01 00:00:00
abstract::Phaeochromocytoma is a rare, usually benign, tumour predominantly managed by endocrinologists. Over the last decade, major advances have been made in understanding the molecular genetic basis of adrenal and extra-adrenal phaeochromocytoma (also referred to as adrenal phaeochromocytoma (aPCA) and extra-adrenal function...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-11-0497
更新日期:2012-02-01 00:00:00
abstract:CONTEXT AND OBJECTIVE:High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0662
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:X-linked adrenoleukodystrophy (X-ALD) is the most frequent, severely neurodegenerative, clinically heterogeneous peroxisomal disorder, the signs of which are a consequence of myelin, adrenal cortex, and testes impairment. OBJECTIVE:We studied testosterone, LH, and FSH levels in X-ALD/adrenomyeloneuropathy (...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0490
更新日期:2012-02-01 00:00:00
abstract::A pheochromocytoma in a pregnant patient is one of the most threatening medical conditions for mother, fetus, and physician. Although extraordinarily rare with a frequency of 0.002% of all pregnancies, this tumor is notorious for its devastating consequences. As in non-pregnant patients, the signs and symptoms are qui...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-11-0528
更新日期:2012-02-01 00:00:00
abstract::Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss s...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-11-0454
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European ...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-0551
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the frequency and characteristics of severe GH deficiency (sGHD) in patients after treatment of acromegaly by surgery alone. DESIGN AND METHODS:One hundred and eighty-six patients fulfilling the criteria for cure of acromegaly were examined by GH-releasing peptide-2 sti...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0657
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:An increased tendency towards thromboembolic events is observed in patients with Cushing's syndrome. There are much fewer publications available about thromboembolic complications in patients with subclinical Cushing's syndrome (SCS). Therefore, a question arises whether hemostatic disturbances appear in this...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0535
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Iodine deficiency has re-emerged in New Zealand, while selenium status has improved. The aim of this study was to investigate the effects of excess iodine intake as iodate on thyroid and selenium status. METHODS:In a randomized controlled trial on older people (mean±s.d. 73±4.8 years; n=143), two groups rece...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-0575
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Although fibroblast growth factor 23 (FGF23) has been implicated in the pathogenesis of cardiovascular disease, the relationship between FGF23 and cardiovascular disease has not been well characterized in the general population. The aim of this study was to determine whether serum FGF23 is independently assoc...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-0577
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry. METHODS:Hyperinsulinemic-euglycemic...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0419
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0131
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:Evidence of the association between vitamin D and cardiovascular risk factors in the young is limited. We therefore assessed the relationships between circulating 25-hydroxyvitamin D(3) (25(OH)D(3)) and metabolic syndrome (MetS), its components, and early atherosclerotic changes in 452 (304 overweight/obese ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0545
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:The intrarenal renin-angiotensin system (RAS) activation plays a pivotal role in immunoglobulin A nephropathy (IgAN) pathogenesis, which is still largely undefined. Recently, vasopressin (AVP) has been advocated to contribute to the genesis and progression of chronic kidney diseases (CKD) directly, and indire...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0512
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Changes in many gastrointestinal peptides, including the anorexigenic peptide YY (PYY), which is produced by L cells, occur in both anorexia nervosa (AN) and obesity (OB). High PYY levels are present in AN, whereas in morbid OB fasting and postprandial PYY secretion is blunted. Somatostatin (somatotropin rele...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0312
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To control postprandial hyperglycemia in insulin-treated type 2 diabetic patients, prandial therapy with regular human insulin (HI) or fast acting insulin analogs is used. Postprandial hyperglycemia seems to be reduced more effectively with insulin analogs than with normal insulin, but there are no data conce...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-0061
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:Several factors either predisposing or protecting from the onset of diabetes mellitus type 2 (DM2) have been proposed. Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or r...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0280
更新日期:2011-08-01 00:00:00